The configuration of nix is not the time consuming part, most of the time it’s faster than other distro if you are a developer. The time consuming part is having an issue with a niche package, the only doc you have is the code and random github issue from 3 years ago that don’t mirror your config, and the nix evaluation doesn’t tell you which part of the config is the problem.
It works for me on graphene in vanadium, Firefox and brave with no compatibility settings changed